Curriculum Vitae

Personal Information:

Carol E. Nicholson, MD, MS, FAAP

Professional Responsibilities

September 2015-2020 (partial list)

Children’s Medical Services, Los Angeles County Department of Court Pediatrician, Edelman Children’s Court. Development of transdisciplinary effort on behalf of the large population of American children in foster placement. Development of research and publication elements, maintenance of certification for pediatricians in Children’s Medical Services.

Consultations to Superior Court/Dependency Court judicial officers as requested in situations of medical complexity in a 30,000 child cohort. These may be as formal consultations to become part of the Court record, or informal consultations to minor’s attorneys.

Organization and supervision of HIPAA compliant records system

Organization of secure delivery system at the Court where high risk material containing important medical information and Court pediatrician recommendations are made available directly and simultaneously to Judicial Officers, Minor’s attorneys, and County Counsel.

Program development of the Court pediatric program: establishment of relationships with judicial officers, minor’s attorney, care providers, and the Department of Family and Child Services, Los Angeles County.

Child Death and Fatality Review: Organization and implementation of Child Death and Fatality Review formal sessions, using modified morbidity and mortality methodology. Relationships with coroner’s office, obtaining reports and interfacing with Medical Examiners and County Coroner personnel.

Year I ICM Instructor, Keck School of Medicine at University of Southern California. Responsibility for teaching first year medical students in diverse medical settings as they learn the approach to the patient, history and physical examination, learning to correlate findings into assessment, as enabled by basic science curriculum, 2016-17.

Developing an efficient and HIPAA-compliant business process for records at Court containing personal health information PHI). Redesign of referral process, providing staging, delivery and storage for sensitive materials.

Development and co-teaching (Ankit Shah MD, JD) of a Child advocacy and Child Health Policy rotation for pediatric residents and fourth year medical students.

November 2001-May 2013

Program Director, Pediatric Critical Care and Rehabilitation Research, National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Center for Medical Rehabilitation Research (NCMRR). Founding, development and management of innovative research program at the NIH.

Founding member of Pediatric Trauma and Critical Illness Branch, 2012. Development over preceding twelve years of portfolio approximately ($40,000,000). Development and management of research capacity strategies in targeted areas.

Project Scientist, Collaborative Pediatric Critical Care Research Network (CPCCRN). This is a national research effort, focusing on improving outcomes for children with complex critical illness and injury, especially those with special health care needs. Voting member of the NIH/NICHD CPCCRN steering committee (see below).

Consultation to NIH, Department of Health and Human Services, Office of the Secretary (DHHS/OS) leadership regarding research and policy affecting emerging threats to child health and preparedness.

Developing partnerships across Federal agencies: with other NIH IC’s (NIMH, NHGRI, NIBIB, and NHLBI), and other agencies: Centers for Disease control (CDC), DHHS/OS/ National Vaccine Program Office (NVPO), Health Resources and Service Agency (HRSA), and the National Science Foundation (NSF).

Negotiation for funds, authorship and publication of scientific initiatives (see below)

Publication of NIH Scientific Initiatives

Innovative Technologies for Pediatric Critical Care and Rehabilitation

http://grants1.nih.gov/grants/guide/rfa-files/RFA-HD-03-014.html

Pediatric Critical Care Scientist Development Program

http://grants1.nih.gov/grants/guide/rfa-files/RFA-HD-03-015.html

Renewal of Pediatric Critical Care Scientist Development Program

http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-08-022.html

Pilot Clinical Trials in the Prevention, Epidemiology and Treatment of Respiratory Failure in Children

http://grants1.nih.gov/grants/guide/rfa-files/RFA-HD-02-027.html

Clinical Trial Planning Grants to Guide and Improve Timing, Intensity, Duration and Outcomes of Pediatric Critical Care and Rehabilitation Therapeutic Interventions in Childhood Cardiopulmonary Arrest http://grants1.nih.gov/grants/guide/rfa-files/RFA-HD-02-026.html

Collaborative Pediatric Critical Care Research Network (CPCCRN)

http://grants1.nih.gov/grants/guide/rfa-files/RFA-HD-04-004.html

http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-08-025.html

Data Coordinating Center (DCC) for National Collaborative Pediatric Critical Care Research Network (CPCCRN)

http://grants1.nih.gov/grants/guide/rfa-files/RFA-HD-04-015.html

http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-08-027.html

Direction of CPCCRN Steering Committee: agenda development, collaboration with Data Coordinating Center (DCC), use of advanced informatics as innovative research management and planning tools. Interactions with clinical sites, assurance that studies and publications meet NIH standards, and official clearance. Development and editing of study protocols for Network Institutional Review Board submissions.

Teaching investigators/applicants to be competitive for research funding: Design and implementation of innovative interventions (online and personally interactive) to elevate science qualities. Change management and leadership of cultural evolution across acute care disciplines: pediatric surgery, anesthesia, neurosurgery, pediatric critical care medicine, pediatric rehabilitation medicine.

Development of innovative funding and co-funding support for pediatric research projects. Resource development with other agencies: HRSA (Health Resources and Service Agency), DARPA (Defense Advanced Research Projects Agency), CDC (Centers for Disease Control), DHHS/OS/Unmet needs: Vaccine program.

Public speaking at professional meetings (partial list):

Pediatric Academic Societies (PAS; 2003, 2004, 2011)
Society of Neurological Surgeons (2003)
Society for Critical Care Medicine (SCCM: 2002, 2006, and 2007)
American College of Rehabilitation Medicine (ACRM: 2003)
Pediatric Acute Lung Injury and Sepsis Investigators (PALISI: 2005, 2006)
United States Critical Illness and Injury Trauma Group (USCIITG: 2012)

Service as pediatric acute care expert advisor for Federal agencies:

Scientific Program Review Subcommittee (Advisory Committee for Injury Prevention and Control at Centers for Disease Control (CDC
Trans-NIH Working Group in Sickle Cell Disease (2003
Trans Federal Child Abuse and Neglect Working Group (CANWG)
Trans-DHHS Working Group in Emergency Medicine: Response to IOM Report: 2007.
Interagency Council on Childhood Emergency Research (ICER)
Center for Emergency Medical Care (CEMC/DHHS), Emergency Care Coordination Center (ECCC) OPEO, Office of the Assistant Secretary for Preparedness and Response
United States Critical Illness and Injury Trial Group, NIH Steering Committee
NIH Task Force on Research in Emergency Settings 2008-10

Peer Review of Scientific Proposals:

Scientific and Program Review Subcommittee, Injury Prevention and Control Center,

Centers for Disease Control 2001-2007.

Department of Energy, Nuclear Cities Initiative, 2003.

National Academy of Sciences, Middle East Research Consortia, 2004, 2009

National Science Foundation, 2007

DHHS/OS Preparedness Initiatives, 2006,2012

Society of Critical Care Medicine: 2006, 2008, 2010, 2011, 2015,2016

United States Critical Illness and Injury Trials Group (2009, 2010, 2011, 2012) CIMIT (Harvard/MIT consortium for innovative medical technology), 2009 CPI (Cerebral Palsy International) 2009

Physicians’ Services Incorporated Foundation (Toronto, ON, Canada) 2010

Great Ormond Street Hospital Foundation (London, UK) 2012

Pediatric Academic Societies, 2011, 2012

Conferences Funded, Planned and Coordinated (Partial List):

Planning conference: Pediatric Critical Care and Rehabilitation Research May 3-4, 2002: Bethesda, MD

Inflicted Childhood Neurotrauma: Transdisciplinary, Evidence-Based Synopsis of Current Science. October 10, 11 2002: Bethesda, MD

Pediatric Pulmonary Practice and Informatics: Evidence-Based Synopsis of Practice and Science. October 4-5, 2003: Bethesda, MD

Pediatric Rehabilitation Research Planning Conference. May 17, 18, 2003: Bethesda, MD.

Pre-application Meeting for Collaborative Pediatric Critical Care Research Network and Data Coordinating Center. May 22, 2003. Bethesda, MD.

Pre-application Meeting for Collaborative Pediatric Critical Care Research Network and Data Coordinating Center. October 2008. Bethesda, MD.

Molecular Aspects of Infection and Inflammation—Common Pathways, Rare Pediatric Diseases. October 5-6, 2004: Bethesda, MD.

Translating Civilian and Defense Technologies for Pediatric Critical Care and Rehabilitation Research. May 17, 18 2004: Rockville, MD.

Oxygen deficit and resuscitation in severe malarial anemia. American Society for Tropical Medicine and Hygiene. May 2006 Atlanta, GA.

Research Experience:

Principal Investigator: Critical Pertussis in US Children: Severe Morbidity, Sequelae, and Mortality. Trans-Federal prospective cohort study of critical pertussis in the USA (critical care unit course and outcomes), originally funded through HHS/OS, Unmet Needs, National Vaccine Program Office (NVPO). http://www.dhhs.gov/nvpo/research/backgrnd.htm Organization of infrastructure leveraging existing support in the Collaborative Pediatric Critical Care Research Network (CPCCRN)in order to facilitate national study through 27 sites; organizing and overseeing outside site training and execution of study. By 2010, 33,000 PICU admissions nationally being surveyed for pertussis, using innovative outside site collaboration training and research by site investigators at 26 sites.

Project Scientist, Collaborative Pediatric Critical Care Research Network: Oversight of execution and design by CPCCRN investigators of multicenter research in critical pertussis, informatics and decision making in pediatric ventilation, bereavement, cortisol activity in septic shock, critical illness immune suppression and nosocomial infection/sepsis, critical asthma research design and development, phenotypic classification of sepsis syndrome and correlation with whole blood mRNA, and molecular biologic changes in regulation of inflammation.

Laboratory Research in a Porcine Model of Hemorrhagic Shock, at the Combat Casualty Care/Resuscitative Medicine directorate at the Naval Medical Research Medical Center, Silver Spring, MD. Present principal project: evaluation of NO scavenger effect and its relationship to systemic and pulmonary hypertension induced in using a blood replacement product, now in Phase II trials for resuscitation.

Fellowship Project: Primary investigator in retrospective cohort study and analysis of monocytes as predictor of outcome and severity of illness in critically ill children with coagulase-negative staphylococcal bacteremia and at high risk for sepsis. Project generated three abstracts for poster presentations and a manuscript for publication.

Past:

Research Project Manager 1991-1992

National Heart, Blood and Lung Institute of National Institute of Health (NHLBI / NIH) and the American Red Cross: Project Manager of the Southern California segment of a large national study of HTLV- I in the transfusion blood supply. Implementation of data and management systems to attain project goals.

Responsibilities included:

Assurance of laboratory and clinical safety. Supervision of staff (research nurse associates, laboratory technicians and secretarial/clerical support staff). Interaction with and manipulation of electronic data systems, compilation and encoding. Coordination with NHLBI/ NIH, the Westat Center in Rockville, MD, and the National Reference Laboratory for Infectious Diseases, American Red Cross. Maintenance of confidentiality of sensitive materials.

Left project to finish residency training, then fellowship.

Prior to Medical School

Research Nurse Manager 1970-1974

University of Southern California Divisions of Human Genetics and Birth Defects Team collaboration and leadership of pediatric research projects in human genetics, prenatal diagnosis, and epidemiology of birth defects, virology, child abuse and neglect. Use of laboratory techniques and informatics as available at the time: consent, tissue recovery, preparation of “squash” plates, culture media for amniocytes, products of conception, and virology specimens. Writing of grants for department, assistance with manuscript preparation for publication. Left position to enter medical school, Fall, 1974.

Professional Background:

Owner, Bicoastal Pediatrics, Inc. 1999 to November 2001

An entrepreneurial startup, providing locum tenens coverage for pediatric critical care, where needed, as well as contract research project management and project development leadership.

Fellowship, Pediatric Critical Care Medicine 1996 to 1999

Children’s Hospital Los Angeles

Postgraduate medical training program in pediatric critical care. Triage, assessment, management, procedures for the critically ill child. Supervision and teaching of residents; theoretical, academic, and research activities.

General Pediatric Practice Experience (Prior to Fellowship):

Medical Director, Sheridan Children’s Hospital Services, Inc. 1995-96

Medical Director of an inpatient pediatric practice in a heavily managed care, for-profit environment.

Valley Medical Center and Children’s Clinic 1995

Comprehensive private pediatric practice in an underserved area of the Northwest (Northern Idaho). Level II neonatal care, comprehensive outpatient and inpatient care, stabilization of critically ill neonates and children and preparation for transport to closest NICU and PICU (250 miles away).

Hospital-based pediatrician, Cedars-Sinai Medical Center 1993-94

Evaluation and management of critically ill children, including advanced life support in collaboration with staff intensivists.

Pediatrician, clinical, Port Hueneme Naval Base 1990-91

Civilian contracted staff physician in pediatric clinic for military dependents, during the Persian Gulf War.

Clinic Pediatrician, H. Claude Hudson Comprehensive Health Center 1982-90

Staff pediatrician, at first part-time (five years), then full-time (two years), in a clinic and walk-in center for urban poor children.

Education:

Bachelor of Science 1969

University of California at Los Angeles

Master of Science 1973

California State University at Los Angeles

Doctor of Medicine 1979

University of Southern California

Professional Designation in Business and Management 1984

UCLA Intensive Business Program (core curriculum similar to MBA)

Professional Post-Graduate Training:

Internship in Pediatrics 1980

(Los Angeles County/USC Medical Center)

Residency in Pediatrics 1992-1993

(University of California at San Diego)

Fellowship, Pediatric Critical Care Medicine 1996-99

(Children’s Hospital Los Angeles)

Certificates and Licenses:

California Physician and Surgeon Certificate and License (G42568)

Other medical licenses: New Jersey, Kansas, Idaho, Virginia, Arizona (inactive)

PALS (Pediatric Advanced Life Support)

NRP (Neonatal Advanced Life Support)

APLS (Advanced Pediatric Life Support)

Board Certification

Diplomate, National Board of Medical Examiners

Diplomate, American Board of Pediatrics, October 1993 (recertification 2003, 2009, 2012)

Diplomate, American Board of Pediatrics, Subspecialty Board, Pediatric Critical Care Medicine (August 2000, Recertification: October 2006, May 2019)

Societies and Honors:

Chairman, Hospital Care Committee, Virginia Chapter, American Academy of Pediatrics 1995-96

Section on Critical Care, American Academy of Pediatrics

Section on Transport Medicine, American Academy of Pediatrics

Council on Children with Disabilities, American Academy of Pediatrics Honored by ICAN as a founder (Interagency Council on Child Abuse and Neglect, Los Angeles County, a model now used nationally)

Society of Critical Care Medicine,

Research Committee Shock Society (2002-2004)

Section on Advanced Therapeutics and Technology, American Academy of Pediatrics 2019

Section on Child Death and Fatality Review, 2017-2019

Fellow, American Academy of Pediatrics, (1993 to present)

Visiting Professor of Pediatrics

Texas Children’s Hospital, Baylor. Houston, TX. November 2007

Saint Justine Hospital for Children. Montreal, Quebec May 2009

University of Pittsburgh, Pittsburgh, PA August 2012

Johns Hopkins University School of Medicine, Baltimore, MD October, 2012

Overseas Fellow Royal Society of Medicine, 2008 to 2013

NICHD (Eunice Kennedy Shriver National Institute of Child Health and Human Development) Director’s Award, 2011

Directors’ Award, National Institutes of Health (NIH), 2010 for the development of research in emergency and critical care settings.

Publications

Textbooks and Monographs.

Nicholson CE and Wetzel RC. Research in Pediatric Critical Care. In Zimmerman J and Fuhrman B (Eds) Pediatric Critical Care. 3rd eds. Philadelphia, PA, USA: Mosby 2005: 29- 54.

Nicholson CE and Wetzel RC. Research in Pediatric Critical Care. In Zimmerman J and Fuhrman B (Eds) Pediatric Critical Care. 4th ed. Philadelphia, PA, USA: Mosby 2011.

Reece RM and Nicholson CE. (Eds). Inflicted Childhood Neurotrauma. Elk Grove Village, IL: American Academy of Pediatrics, 2003.

Koroshetz WJ; NIH Task Force on Research in Emergency Settings. NIH and research in the emergency setting: progress, promise and process. Ann Emerg Med. 2010 Nov; 56(5):565-7.

D’Onofrio G, Jauch E, Jagoda A, Allen MH, Anglin D, Barsan WG, Berger RP, Bobrow BJ, Boudreaux ED, Bushnell C, Chan YF, Currier G, Eggly S, Ichord R, Larkin Gl, Laskowitz D, Neurmar RW, Newman-Toker DE, Quinn J, Shear K, Todd KH, Zatzick D; Roundtable External Participants and Roundtable Steering Committee and Federal Participants. NIH Roundtable on Opportunities to Advance Research on Neurologic and Psychiatric Emergencies. Ann Emerg Med. 2010 Nov; 56(5):551-64.

Cairns CB, Maier RV, Adeoye O, Baptiste D, Barsan WG, Blackbourne L, Burd R, Carpenter C, Chang D, Cioffi W, Cornwell E, Dean JM, Dyer C, Jaffe D, Manley G, Meurer WJ, Neumar R, Silbergleit R, Stevens M, Wang M, Weiner D; Roundtable External Participants and Roundtable Steering committee and Federal Participants. NIH Roundtable on Emergency and Trauma Research. Ann Emerg Med. 2010 Nov; 56(5): 538-50.

Peer-reviewed Journals

Bailly DK, Reeder RW, Winder M, Barbaro RP, Pollack MM, Moler FW, Meert KL, Berg RA, Carcillo J, Zuppa AF, Newth C, Berger J, Bell MJ, Dean MJ, Nicholson C, Garcia-Filion P, Wessel D, Heidemann S, Doctor A, Harrison R, Bratton SL, Dalton H; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN). Development of the Pediatric Extracorporeal Membrane Oxygenation Prediction Model for Risk-Adjusting Mortality. Pediatr Crit Care Med. 2019 May;20(5):426-434. Doi: 10.1097/PCC.0000000000001882. PMID: 30664590

Berger JT, Villalobos ME, Clark AE, Holubkov R, Pollack MM, Berg RA, Carcillo JA, Dalton H, Harrison R, Meert KL, Newth CJL, Shanley TP, Wessel DL, Anand KJS, Zimmerman JJ, Sanders RC Jr, Liu T, Burr JS, Wilson DF, Doctor A, Dean JM, Jenkins TL, Nicholson CE; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. Cognitive Development One Year After Infantile Critical Pertussis. Pediatr Crit Care Med. 2018 Feb;19(2):89-97. Doi: 10.1097/PCC.0000000000001367. PMID: 29117060

Newth CJL, Sward KA, Khemani RG, Page K, Meert KL, Carcillo JA, Shanley TP, Moler FW, Pollack MM, Dalton HJ, Wessel DL, Berger JT, Berg RA, Harrison RE, Holubkov R, Doctor A, Dean JM, Jenkins TL, Nicholson CE; Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN). Variability in Usual Care Mechanical Ventilation for Pediatric Acute Respiratory Distress Syndrome: Time for a Decision Support Protocol? Pediatr Crit Care Med. 2017 Sep 19. doi: 10.1097/PCC.0000000000001319. [Epub ahead of print] PMID: 28930815

Sward KA, Newth CJL, Khemani RG, Page K, Meert KL, Carcillo JA, Shanley TP, Moler FW, Pollack MM, Dalton HJ, Wessel DL, Berger JT, Berg RA, Harrison RE, Doctor A, Dean JM, Holobkov R, Jenkins TL, Nicholson CE; Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN). Potential Acceptability of a Pediatric Ventilator Management Computer Protocol. Pediatr Crit Care Med. 2017 Sep 16. doi: 10.1097/PCC.0000000000001331. [Epub ahead of print] PMID: 28926488

Dalton HJ, Reeder R, Garcia-Filion P, Holubkov R, Berg RA, Zuppa A, Moler FW, Shanley T, Pollack MM, Newth C, Berger J, Wessel D, Carcillo J, Bell M, Heidemann S, Meert KL, Harrison R, Doctor A, Tamburro RF, Dean JM, Jenkins T, Nicholson C; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. Factors Associated with Bleeding and Thrombosis in Children Receiving Extracorporeal Membrane Oxygenation.Am J Respir Crit Care Med. 2017 Sep 15;196(6):762-771. doi: 10.1164/rccm.201609-1945OC. PMID: 28328243

Carcillo JA, Dean JM, Holubkov R, Berger J, Meert KL, Anand K Zimmerman J, Newth CJ, Harrison R, Burr J, Willson DF, Nicholson C, Bell MJ, Berg Ra, Shanley TP, Heidemann SM, Dalton H, Jenkins TL, Doctor A, Webster A: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN). Inherent Risk Factors for Nosocomial Infection in the Long Stay Critically Ill Child without Known Baseline Immunocompromise. Pediatr Inf Dis J. 2016 Jun 30 [Epub ahead of print] PMID 27379619

Carcillo JA, Dean JM, Holubkov R, Berger J, Meert KL, Anand KJ, Zimmerman JJ, Newth CJ, Harrison R, Burr J, Willson DF, Nicholson C, Bell MJ, Berg RA, Shanley TP, Heidemann SM, Dalton H, Jenkins TL, Doctor A, Webster A, Tamburro RF; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN). Interaction between 2 Nutraceutical Treatments and Host Immune Status in the Pediatric Critical Illness Stress-Induced Immune Suppression Comparative Effectiveness Trial. J Parenter Enteral Nutr. 2016 Sep 22. pii: 0148607116670377. [Epub ahead of print]

Zimmerman JJ, Anand KJ, Meert KL, Willson DF, Newth CJ, Harrison R, Carcillo JA, Berger J, Jenkins TL, Nicholson C, Dean JM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. Research as a Standard of Care in the PICU. Pediatr Crit Care Med. 2016 Jan; 17(1): e13-21. PMID 26513203

Jardine D, Edmond M, Meert KL, Harrison R, Carcillo JA, Anand KJ, Berger J, Newth CJ, Willson DF, Nicholson C, Dean JM, Zimmerman JJ for the Eunice Kennedy Shriver National Institute of Child Health and Human Development. A Single Nucleotide Polymorphism in the Corticotropin Receptor Gene is Associated with a Blunted Cortisol Response during Pediatric Critical Illness. Pediatr Crit Med. 2014 July 22. [Epub ahead of print] PMID 25055195.

Meert KL, Eggly S, Berg RA, Wessel DL, Newth CJ, Shanley TP, Harrison R, Dalton H, Clark AE, Dean JM, Doctor A, Nicholson CE; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. Feasibility and Perceived Benefits of a Framework for Physician-Parent Follow-Up Meetings after a Child's Death in the PICU. Crit Care Med. 2014 Jan; 42(1):148-57.

Berg RA, Sutton RM, Holubkov R, Nicholson CE, Dean JM, Harrison R, Heidemann S, Meert K, Newth C, Moler F, Pollack M, Dalton H, Doctor A, Wessel D, Berger J, Shanley T, Carcillo J, Nadkarni VM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network and for the American Heart Association’s Get With the Guidelines-Resuscitation (formerly the National Registry of Cardiopulmonary Resuscitation) Investigators. Ratio of PICU versus ward cardiopulmonary resuscitation events is increasing. Crit Care Med. 2013 Oct; 41(10):2292-7.

Pollack MM, Dean JM, Butler J, Holubkov R, Doctor A, Meert KL, Newth CJ, Berg RA, Moler F, Dalton H, Wessel DL, Berger J, Harrison RE, Carcillo JA, Shanley TP, Nicholson CE. The Ideal Time Interval for Critical Care Severity-of Illness Assessment. Pediatr Crit Care Med. 2013 Jun; 14(5):448-53.

Berger JT, Carcillo JA, Shanley TP, Wessel DL, Clark A, Holubkov R, Meert KL, Newth CJ, Berg RA, Heidemann, S, Harrison R, Pollack MM, Dalton H, Harvill E, Karanikas A, Liu T, Burr JS, Doctor A, Dean JM, Jenkins TL, Nicholson CE; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN). Critical pertussis illness in children: a multicenter prospective cohort study. Pediatr Crit Care Med. 2013 May; 14(4):374-83.

Holubkov R, Casper TC, Dean JM, Anand KJ, Zimmerman JJ, Meert KL, Newth CH, Berger J, Harrison R, Willson DF, Nicholson C; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN). The role of the Data and Safety Monitoring Board in a clinical trial: the CRISIS study. Pediatr Crit Care Med. 2013 May; 14(4):374- 83.

Heidemann SM, Holubkov R, Meert KL, Dean JM, Berger J, Bell M, Anand KJ, Zimmerman J, Newth CJ, Harrison R, Willson DF, Nicholson C, Carcillo J; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN). Baseline serum concentrations of zinc, selenium, and prolactin in critically ill children. Pediatr Crit Care Med. 2013 May; 14(4): e202-6.

Bratton SL, Newth CJ, Zuppa AF, Moler FW, Meert KL, Berg RA, Berger J, Wessel D, Pollack M, Harrison R, Carcillo JA, Shanley TP, Liu T, Holubkov R, Michael Dean J, Nicholson CE, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. Critical care for pediatric asthma: Wide care variability and challenges for study. Pediatr Crit Care Med. 2012 Jul; 13(4):407-414 PubMed PMID: 22067984.

Newth CJL, Meert KL, Clark AE, Moler FW, Zuppa AF, Berg RA, Pollack MM, Sward KA, Berger JT, Wessel DL, Harrison RE, Reardon J, Carcillo JA, Shanley TP, Holubkov R, Dean JM, Doctor A, Nicholson CE. Fatal and near-fatal asthma in children: the critical care perspective. J Pediatr. 2012 Aug; 161(2):214-21. e3. Epub 2012 Apr 10.

PMID: 22494876

Carcillo JA, Dean JM, Holubkov R, Berger J, Meert KL, Anand KJ, Zimmerman J, Newth CJ, Harrison R, Burr J, Willson CC, Nicholson C. The randomized comparative pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial. Pediatr Crit Care Med. 2012 Mar; 13(2):165-173; PubMed PM1D:22079954. PubMed Central PMCID: PMC3302948

Anand KJS, Clark AE, Willson DF, Berger J, Meert KL, Zimmerman JJ, Harrison R, Carcillo JA, Newth CJL, Bisping S, Dean JM, Nicholson CE for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Collaborative Pediatric Critical Care Research Network (CPCCRN). Opioid analgesia in mechanically ventilated children: results from the multicenter MOTIF study.

Pediatr Crit Care Med 2012. Nov 5 [Epub ahead of print] PMID 23132396.

Nicholson CE. Early exchange and pheresis therapies in critical pertussis. Pediatr Crit Care Med. 2011 Mar; 12(2):240-1.

Meert KL, Shear K, Newth CJ, Harrison R, Berger J, Zimmerman J, Anand KJ, Carcillo J, Donaldson AE, Dean JM, Willson DF, Nicholson CE. Follow-up study of complicated grief among parents eighteen months after a child’s death in the pediatric intensive care unit. J Palliat Med. 2011 Feb; 14(2):207-14. Epub 2011 Jan 31.

Burr JS, Jenkins TL, Harrison R, Meert K, Anand KJ, Berger JT, Zimmerman J, Carcillo J, Dean JM, Newth CJ, Willson DF, Sanders RC, Pollack MM, Harvill E, Nicholson CE. The Collaborative Pediatric Critical Care Research Network (CPCCRN) Pertussis Study: Collaborative Research in Pediatric Critical Care Medicine. Pediatr Crit Care Med. 2011 Jul;12(4):387-92.

Meert KL, Donaldson AE, Newth CJ, Harrison R, Berger J, Zimmerman J, Anand KJ, Carcillo J, Dean JM, Willson DF, Nicholson CE, Shear K. Complicated grief and associated risk factors among parents following a child’s death in the pediatric intensive care unit. Arch Pediatr Adolesc Med. 2010 Nov; 164(11):1045-51.

Eggly S, Meert KL, Berger J, Zimmerman J, Anand KJ, Newth CH, Harrison R, Carcillo J, Dean JM, Willson DF, Nicholson CE A framework for conducting follow-up meetings with parents after a child’s death in the pediatric intensive care unit. Pediatr Crit Care Med. 2011 Mar 12(2):147-52.

Anand KJ, Willson DF, Berger J, Harrison R, Meert KL, Zimmerman J, Carcillo J, Newth CJ, Prodhan P, Dean JM, Nicholson CE. Tolerance and withdrawal from prolonged opioid use in critically ill children. Pediatrics. 2010 May; 125(5): e1208-25. Epub 2010 Apr 19.

Zimmerman JJ, Donaldson A, Barker RM, Meert KL, Harrison R, Carcillo JA, Anand KJ, Newth CJ, Berger J, Willson DF, Jack R, Nicholson CE, Dean JM. Real-time free cortisol quantification among critically ill children. Pediatr Crit Care Med 2010 Nov 4. [Epub ahead of print]

Eggly S, Meert KL, Berger J, Zimmerman J, Anand KJ, Newth CJ, Harrison R, Carcillo J, Michael Dean J, Willson DF, Nicholson CE; the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. A framework for conducting follow-up meetings with parents after a child's death in the pediatric intensive care unit. Pediatr Crit Care Med. 2010 Jul 9. [Epub ahead of print]

Meert KL, Eggly S, Berger J, Zimmerman J, Anand KJ, Newth CJ, Harrison R, Carcillo J, Dean JM, Willson DF, Nicholson CE; the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. Physicians' experiences and perspectives regarding follow-up meetings with parents after a child's death in the pediatric intensive care unit. Pediatr Crit Care Med.

2010 Jun 24. [Epub ahead of print] PMID: 20581729.

Carcillo J, Holubkov R, Dean JM, Meert KL, Berger J, Anand KJS, Zimmerman JJ, Harrison R, Newth CJ, Willson DF, Nicholson CE. Rationale and Design of the Pediatric Critical Illness Stress-Induced Immune Suppression Prevention Trial.

J Parenter Enteral Nutr. 2009 April 21. Epub ahead of print.

Willson DF, Dean JM, Meert KL, Newth CJ, Anand KJ, Berger J, Harrison R, Zimmerman J, Carcillo J, Pollack M, Holubkov R, Jenkins TL, Nicholson CE; Eunice Kennedy Shriver National Institute of Child Health, and Human Development Collaborative Pediatric Critical Care Research Network. Collaborative pediatric critical care research network: looking back and moving forward. Pediatr Crit Care Med. 2010 Jan 11(1):1-6.

Anand KJ, Willson DF, Berger J, Harrison R, Meert KL, Zimmerman J, Carcillo J, Newth CJ, Prodhan P, Dean JM, Nicholson CE; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. Tolerance and withdrawal from prolonged opioid use in critically ill children. Pediatrics. 2010 May; 125(5): e1208-25. Epub 2010 Apr 19. Review.PMID:20403936

Newth CJ, Venkataraman S, Willson DF, Meert KL, Harrison R, Dean JM, Pollack M, Zimmerman J, Anand KJ, Carcillo JA, Nicholson CE; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. Weaning and extubation readiness in pediatric patients. Pediatr Crit Care Med 2009 Jan: 10(1):1-11.

Gordon C, Barton E, Meert KL, Eggly S, Pollack M, Zimmerman J, Anand KJ, Carcillo J, Newth CJ, Dean JM, Willson DF, Nicholson C; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. Accounting for medical communication: parents' perceptions of communicative roles and responsibilities in the pediatric intensive care unit. Commun Med. 2009; 6(2):177-88.

Nicholson CE, Dean JM. Looking for truth: in ourselves and in those we train. Pediatr Crit Care Med. 2009 May; 10(3):417-8. No abstract available. PMID: 19433953.

Holubkov R, Dean JM, Berger J, Anand KJS, Carcillo J, Meert K, Zimmerman J, Newth CJ, Harrison R, Willson DF, Nicholson C, and the Eunice Kennedy Shriver NICHD Collaborative Pediatric Critical Care Research Network. Is “rescue” therapy ethical in randomized controlled trials? Pediatr Crit Care Med 2009 Feb 27. Epub ahead of print.

Pollack M, Glass P, Holubkov, Dean JM, Willson DF, Meert KL Anand KM, Newth CJ, Carcillo J, Nicholson CE. The functional status score (FSS): A new pediatric outcome measure. Pediatrics, 2009 Jul; 124(1): e18-28.

Kathleen Lynn Meert, Susan Eggly, J. Michael Dean, Murray Pollack, Jerry Zimmerman,

K.J.S. Anand, Christopher J.L. Newth, Douglas F. Willson, Carol Nicholson. Ethical and Logistic considerations of multicenter parental bereavement research. J Palliat Med. April 1, 2008, 11(3): 444-450.

Meert KL, Eggly S, Pollack M, Anand KJ, Zimmerman J, Carcillo J, Newth CJ, Dean JM, Willson DF, Nicholson C; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. Parents' perspectives on physician-parent communication near the time of a child's death in the pediatric intensive care unit. Pediatr Crit Care Med. 2008 Jan; 9(1):2-7.

Meert KL, Eggly S, Pollack M, Anand KJ, Zimmerman J, Carcillo J, Newth CJ, Dean JM, Willson DF, Nicholson C. NICHD Collaborative Pediatric Critical Care Research Network (CPCCRN). Parents’ perspectives regarding a physician-parent conference after their child’s death in the pediatric intensive care unit. J Pediatr. 2007 Jul; 151 (1): 50-55.

Nicholson CE Critical pertussis may model organ failure in critical illness and injury.

Pediatr Crit Care Med. 2007 May: 8(3):288-9.

Shudy M, deAlmeida ML, Ly S, Landon C, Groft S, Jenkins TL, Nicholson CE. Impact of pediatric critical illness and injury on families: a systematic literature review. Pediatrics. 2006 Dec:118 Suppl3:S203-18. Review.

Willson DF, Dean JM, Newth C, Pollack M, Anand KJ, Meert K, Carcillo J, Zimmerman J, Nicholson C. Collaborative Pediatric Critical Care Research Network (CPCCRN).

Pediatr Crit Care Med 2006 Jul; 7(4):301-7.

Arnaud F, Hammett M, Asher L, Philbin N, Rice J, Dong F, Pearce B, Flournoy, WS, Nicholson CE, McCarron R and Freilich D. Effects of bovine polymerized hemoglobin (HBOC-201) on coagulation in controlled hemorrhagic shock in swine. Shock 2005; 24(2): 145-152.

Wagner NJ, Quatrano LA, and Nicholson CE. Translating Civilian and Defense Technology for Pediatric Critical Care and Rehabilitation Research. Technol Health Care. 2006; 14(1): 49-58.

Nicholson CE, Gans BM et al. Pediatric critical care medicine: planning for our research future. Pediatr Crit Car Med. 2003 Apr;4(2): 196-202.

Nicholson CE. Pediatric critical care for children with congenital neurodevelopmental diagnoses. Pediatr Crit Care Med 2004 Jul; 5(4) 407-8.

Abstracts and posters (partial):

Garcia-Filion P, Dalton H, Rycus P, Dean JM, Nicholson C. Extracorporeal Life support (ECLS): Does reducing complications improve outcome? Pediatric Academic Societies. Boston, MA. April/May 2012.

Garcia-Filion P, Dalton H, Rycus P, Dean JM, Nicholson C. Extracorporeal life support (ECLS): Clinical correlates of survival in the NICHD Collaborative Pediatric Critical Care Research Network (CPCCRN). Pediatric Academic Societies. Boston, MA. April/May 2012.

Zimmerman JJ et al. for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN). Centrifugal ultrafiltration (CU) is essentially equivalent to equilibrium dialysis (ED) for fractionation of free cortisol (FC). Society of Critical Care Medicine, World Congress: Nashville, TN. February 2009.

Meert KL, Eggly S. et al. for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN). Physicians’ perspectives on follow-up conferences with parents after a child’s death in the PICU. Accepted for presentation at Society of Critical Care Medicine, World Congress: Nashville, TN.

February 2009.

Nicholson CE, Broder K, Carcillo J and Slade BA. Immunophenotyping, organ failure, and Bordetella pertussis critical illness in children. In Death Danger and Immunity (Mort Cellulaire, Danger et Immunite) Institut Pasteur, Centre d’Information Scientifique, Paris, France March, 2007.

Arnaud F, Tomori, T, Saito, R, McCarron, RM and Nicholson CE. “Predictors of Survival in a Rapid Hemorrhage Porcine Model.” Submitted for presentation at Society of Critical Care Medicine for January 2006 World Congress.

Francois Arnaud, Mike Hammett, Feng Dong, Jennifer Rice, Nora Philbin, Bruce Pearce, Richard McCarron, Carol Nicholson and Daniel Freilich. “Hemostatic effects of HBOC- 201 in a swine hemorrhagic shock (HS) model with controlled hemorrhage.” August 2004.

Nicholson CE.; Arnaud F, Philbin N, Rice J, Dong F, Freilich D and McCarron RM. “Gender, mortality and pulmonary artery pressure in a swine model of hemorrhagic shock.” Society of Critical Care Medicine. January 2005.

Nicholson CE et al: “Absolute number of monocytes predicts number of mechanical ventilation hours in critically ill staphylococcal coagulase-negative bacteremic children.” Am J Respir Crit Care Med 1999 March; 159 (3) A603.

Nicholson CE, Shaikh A, Tan S, Peters R and Wetzel, RC. “Time to Culture positivity does not predict outcome in critically ill children with staphylococcal coagulase-negative bacteremia.” Society of Critical Care Medicine, San Francisco. January 1999.

Weiner DL, Nicholson CE and Guttmacher AE. “Application of Functional Genomics to Disease Processes: A Research Priority for Approach to the Study of Rare Pediatric Critical Illness.” Functional Genomics of Critical Illness and Injury, National Institutes of Health, April, 2008.

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